Creamy, cheesy, and satisfyingly hearty, this Meatloaf and Cheddar Shells Casserole is about to become your new family favorite. Imagine the comforting flavors of classic meatloaf, layered with tender, cheddar-coated pasta shells—all baked together into a bubbling, golden casserole that brings everyone rushing to the table. Growing up, casseroles like this were a staple on busy weeknights, and there was always a dash of excitement when the savory goodness made its way out of the oven. What makes this recipe stand out is its simplicity and crowd-pleasing nature. Unlike my popular Cheesy Chicken Pasta Bake, this dish uses budget-friendly beef and pasta but delivers the same rich, comforting taste that brings people back for seconds. Give this Meatloaf and Cheddar Shells Casserole a try, and watch everyone ask for the recipe—it’s that good!
What is Meatloaf and Cheddar Shells Casserole ?
With a name like Meatloaf and Cheddar Shells Casserole, you might be asking yourself, “Is it meatloaf or is it mac and cheese?” Well, why not both? This dish hilariously combines the best of a classic meatloaf base with everyone’s favorite cheesy shells, all baked into a single, oh-so-comforting casserole. Who came up with the idea? Maybe someone who couldn’t decide what to make for dinner! As the old saying goes, “the way to a man’s heart is through his stomach,” and this casserole surely delivers. If you’re ready to wow your crowd with a dish that’s both familiar and delightfully unexpected, pull up your sleeves and give this recipe a go!
Why You’ll Love This
The biggest highlight of this Meatloaf and Cheddar Shells Casserole is the flavor-packed combination of juicy beef, perfectly seasoned and pressed into a hearty base, topped with creamy cheddar shells that melt into every bite. Not only does this recipe taste incredible, but it’s also easy on your wallet—using everyday, affordable ingredients found in nearly every pantry. What takes this recipe over the top is the sharp cheddar, rich tomato sauce, and those adorable pasta shells that soak up every bit of saucy goodness. If you loved my Easy Baked Ziti recipe, you’ll appreciate the similar comfort this casserole provides, with a beefy twist. Don’t take my word for it—try it yourself and see how quickly it disappears at your table!
How to Make Meatloaf and Cheddar Shells Casserole
Quick Overview
This casserole is a dream for busy nights—easy to assemble, deliciously rich, and incredibly satisfying. The prep is straightforward: layer a simple meatloaf base, top it with a cozy blend of cheddar-laced pasta shells, and bake to perfection. In less than an hour (including only 10-15 minutes active prep time), you’ll have a bubbly, comforting meal ready to serve. The creamy sauce and golden cheese make this casserole irresistible from the first forkful to the last.
Ingredients
- 1 lb ground beef
- 1/2 cup breadcrumbs
- 1 cup shredded cheddar cheese
- 1 can (10.75 oz) condensed tomato soup
- 1 cup milk
- 1/2 teaspoon garlic powder
- 1/2 teaspoon onion powder
- Salt and pepper, to taste
- 8 oz medium pasta shells, cooked and drained
Directions
- Preheat your oven to 350°F (175°C). Grease a 9×13-inch baking dish and set aside.
- In a large mixing bowl, combine the ground beef, breadcrumbs, garlic powder, onion powder, salt, and pepper. Mix thoroughly until the ingredients are evenly distributed.
- Press the meatloaf mixture evenly into the bottom of your prepared baking dish, forming a solid layer.
- In another bowl, mix together the cooked pasta shells, shredded cheddar cheese, condensed tomato soup, and milk. Stir until well combined and creamy.
- Spoon the cheddar shells mixture evenly over the meatloaf layer in the baking dish, spreading gently to cover.
- Cover the baking dish with foil and bake in the preheated oven for 30 minutes.
- Remove the foil and continue baking for an additional 10-15 minutes, or until the casserole is bubbly and the cheese is fully melted on top.
- Let the casserole cool for about 10 minutes for easier serving. Scoop onto plates and enjoy!
What to Serve With
Pair this hearty casserole with a crisp green salad tossed in a zesty vinaigrette to refresh the palate. Garlic bread or warm dinner rolls are perfect for soaking up any extra sauce. For veggies, try steamed broccoli or roasted carrots to add color and balance to the meal. If you want a simple drink pairing, a glass of iced tea or lemonade works beautifully, keeping the meal light and family-friendly.
Top Tips for Perfecting Meatloaf and Cheddar Shells Casserole
- For a leaner option, substitute ground turkey or chicken for beef.
- Try different cheeses, like Monterey Jack or pepper jack, for a fun twist on flavor.
- Add cooked, diced veggies (like bell peppers or spinach) into the meatloaf mixture for extra nutrition.
- Don’t overbake, as this can dry out the casserole. Remove from the oven when it’s just bubbly and the cheese has melted.
- For a crispier cheese topping, broil the casserole for 2-3 minutes after baking (watch closely!).
- If you’re pressed for time, assemble ahead and refrigerate until ready to bake.
Storing and Reheating Tips
Store leftovers in an airtight container in the refrigerator for up to 4 days. To reheat, place individual portions in the microwave for 1-2 minutes, or until hot throughout. If you’d like to reheat the entire casserole, cover with foil and warm in a 350°F oven for 15-20 minutes. This casserole also freezes well—wrap tightly with plastic wrap and foil, and store for up to 2 months. Thaw in the refrigerator overnight before reheating in the oven.
FAQs
Can I use a different type of pasta?
Yes! While medium shells are classic, feel free to use elbow macaroni, rotini, or penne if that’s what you have on hand.
Is this recipe gluten-free?
You can easily make it gluten-free by using gluten-free breadcrumbs and pasta.
Can I prepare this casserole in advance?
Absolutely. You can assemble it up to a day ahead, refrigerate, and bake when ready to serve.
What can I use if I don’t have condensed tomato soup?
A mix of tomato sauce with a splash of cream or milk will give you a similar creamy, tangy result.
How can I make this recipe spicier?
Add a pinch of red pepper flakes, diced jalapenos, or use pepper jack cheese for an extra kick.
Conclusion
Meatloaf and Cheddar Shells Casserole is the definition of weeknight comfort—creamy, hearty, and endlessly flavorful. With its easy prep, budget-friendly ingredients, and reliable crowd-pleasing appeal, it’s perfect for family dinners or meal prep. Whether you’re cooking for a group or looking to cozy up with leftovers, this casserole delivers every time. Don’t forget to check out other comforting casseroles on the blog and let me know how this recipe turns out for you in the comments—happy cooking!

Meatloaf and Cheddar Shells Casserole
Equipment
- Mixing Bowl
- Baking Dish
Ingredients
Meatloaf Base
- 1 lb Ground Beef
- 1/2 cup Breadcrumbs
- 1/2 teaspoon Garlic Powder
- 1/2 teaspoon Onion Powder
Cheddar Shells
- 1 cup Shredded Cheddar Cheese
- 1 can (10.75 oz) Condensed Tomato Soup
- 1 cup Milk
- 8 oz Medium Pasta Shells, cooked and drained
Instructions
- Preheat your oven to 350°F (175°C). Grease a 9×13-inch baking dish and set aside.
- In a large mixing bowl, combine the ground beef, breadcrumbs, garlic powder, onion powder, salt, and pepper. Mix thoroughly until the ingredients are evenly distributed.
- Press the meatloaf mixture evenly into the bottom of your prepared baking dish, forming a solid layer.
- In another bowl, mix together the cooked pasta shells, shredded cheddar cheese, condensed tomato soup, and milk. Stir until well combined and creamy.
- Spoon the cheddar shells mixture evenly over the meatloaf layer in the baking dish, spreading gently to cover.
- Cover the baking dish with foil and bake in the preheated oven for 30 minutes.
- Remove the foil and continue baking for an additional 10-15 minutes, or until the casserole is bubbly and the cheese is fully melted on top.
- Let the casserole cool for about 10 minutes for easier serving. Scoop onto plates and enjoy!