Name: Spinach Chicken Casserole with Cream Cheese and Mozzarella
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Ingredients: 2 cups cooked chicken, shredded; 2 cups fresh spinach, chopped; 8 oz cream cheese, softened; 1 cup mozzarella cheese, shredded; 1/2 cup sour cream; 1/2 cup chicken broth; 1 teaspoon garlic powder; 1 teaspoon onion powder; Salt and pepper to taste; 1/2 teaspoon red pepper flakes (optional); 1/2 cup breadcrumbs (for topping)

Jump to Recipe

There’s just something about a creamy, bubbling casserole that makes dinnertime feel extra special, isn’t there? Spinach Chicken Casserole with Cream Cheese and Mozzarella is a celebration of flavors and textures—juicy chicken, silky cream cheese, melty mozzarella, and tender spinach come together with a crunchy golden topping for a meal that feels both comforting and a little indulgent. Did you know casseroles became wildly popular in American kitchens during the mid-20th century because they were an easy, filling solution for busy weeknights? This dish is a modern spin on those retro classics, but a whole lot tastier! If you love the easy, family-friendly appeal of my Creamy Tuscan Chicken Pasta, you’ll swoon for this casserole too. Read on and get ready to discover your new favorite dinner—warm, wonderful, and absolutely impossible to resist!

What is Spinach Chicken Casserole with Cream Cheese and Mozzarella?

What’s in a name? Well, in this case, everything you need to know! This dish combines juicy chicken and fresh spinach in a dreamy cream cheese sauce, topped off with melty mozzarella and crispy breadcrumbs. Sound like a mouthful? It sure is—in the best possible way! Legend has it that the way to a man’s heart is through his stomach, and this casserole just might prove it true. Who says delicious comfort food can’t also be a little playful? Don’t just take my word for it—get into the kitchen, try this cheesy wonder, and let your taste buds do the talking.

Why You’ll Love This

The star of this casserole is undoubtedly its glorious, melt-in-your-mouth cream cheese sauce—luxurious, but easy enough to whip up on a weeknight. Making this meal at home is not only budget-friendly (store-bought casseroles or takeout can’t compete!), but also guarantees fresher flavors and the ability to customize to your liking. Loaded with shredded chicken, vibrant spinach, and a decadent layer of mozzarella, each bite is as satisfying as the last. The crispy breadcrumb topping adds just the right amount of crunch, creating textural magic that sets this casserole apart. If you’ve enjoyed my Baked Chicken Alfredo Casserole, you’ll love this spin—give it a try, invite your friends, and watch it disappear!

How to Make

Quick Overview

Spinach Chicken Casserole with Cream Cheese and Mozzarella is surprisingly easy to pull together, with minimal prep and straightforward steps. This dish is all about comfort and speed—you only need around 15 minutes of hands-on prep time, plus baking. The hardest part? Waiting for that cheesy, bubbling casserole to come out of the oven! With juicy chicken, a creamy, craveable sauce, and a crispy topping, this dish delivers maximum satisfaction with minimal effort.

Ingredients

2 cups cooked chicken, shredded
2 cups fresh spinach, chopped
8 oz cream cheese, softened
1 cup mozzarella cheese, shredded
1/2 cup sour cream
1/2 cup chicken broth
1 teaspoon garlic powder
1 teaspoon onion powder
Salt and pepper to taste
1/2 teaspoon red pepper flakes (optional)
1/2 cup breadcrumbs (for topping)

Step-by-Step

Preheat your oven to 375°F (190°C), and lightly grease a baking dish (about 9×13 inches).
In a large mixing bowl, combine the softened cream cheese, sour cream, chicken broth, garlic powder, onion powder, salt, pepper, and red pepper flakes (if using). Whisk until the mixture is smooth and creamy.
Fold in the shredded chicken and chopped spinach, mixing until all the ingredients are evenly coated.
Transfer the mixture to the prepared baking dish, spreading it into an even layer.
Sprinkle the shredded mozzarella cheese over the top.
Evenly distribute the breadcrumbs across the mozzarella layer for a golden, crispy finish.
Bake in the preheated oven for 25–30 minutes, or until the casserole is hot and bubbly and the breadcrumbs are golden brown.
Remove from the oven and let the casserole rest for about 5 minutes before serving. This allows the cheesy sauce to thicken slightly for the perfect scoopable texture!

What to Serve With

This casserole is a meal in itself, but it also pairs beautifully with a crisp green salad dressed with a tangy vinaigrette to balance the richness. For extra comfort, serve it with warm garlic bread or a fluffy dinner roll—perfect for soaking up every bit of that delicious sauce. Steamed broccoli, roasted asparagus, or sautéed green beans also make fresh, bright sides that round out the meal. For drinks, a sparkling lemonade or a glass of chilled white wine complements the creamy flavors beautifully.

Top Tips for Perfecting

If you’re out of fresh spinach, frozen chopped spinach (thawed and squeezed dry) works just as well.
Don’t overbake—keep an eye on the casserole once the breadcrumbs start turning golden to ensure your chicken stays moist.
Want even more flavor? Stir in a handful of sun-dried tomatoes or swap mozzarella for a sharp provolone or fontina.
For a gluten-free version, use gluten-free breadcrumbs or crushed pork rinds for the topping.
Letting the casserole rest after baking not only makes it easier to serve, but also helps the flavors meld and the texture firm up.

Storing and Reheating Tips

To store leftovers, allow the casserole to cool to room temperature before transferring it to an airtight container. Refrigerate for up to 4 days. To reheat, place a serving in a microwave-safe dish and heat in 30-second bursts until warm, or bake in a 350°F (175°C) oven, covered with foil, for about 15–20 minutes. Want to freeze? Wrap individual portions tightly and freeze for up to 2 months—thaw overnight in the fridge and reheat as above for a quick, delicious meal.

FAQs

Can I use rotisserie chicken for this recipe?
Absolutely! Rotisserie chicken is a fantastic shortcut and adds plenty of flavor.

What if I don’t have cream cheese?
You can substitute with Neufchâtel cheese or even a thick Greek yogurt, but cream cheese gives the richest texture.

Does this recipe work with other greens?
Yes, try chopped kale or Swiss chard as a substitute, or even a mix for extra color and nutrients.

Can I prepare this casserole ahead of time?
Yes! Assemble the casserole up to a day in advance, cover, and refrigerate. Add breadcrumbs just before baking for best crunch.

How do I make this dish vegetarian?
Swap the chicken for hearty mushrooms or roasted cauliflower, and use vegetable broth instead of chicken broth for a delicious vegetarian version.

Conclusion

Spinach Chicken Casserole with Cream Cheese and Mozzarella is comfort food perfection—creamy, cheesy, and loaded with flavor. It’s quick to prepare, easy to customize, and guaranteed to bring smiles to your table. Whether you’re looking for a cozy family dinner, a meal-prep favorite, or a dish to share with friends, this casserole hits all the right notes. Don’t forget to explore more recipes on the blog for easy, satisfying meals your family will love. Try this one soon and watch it earn a permanent spot in your weekly dinner rotation!